Welcome to Yang Lab at Northwestern

The Yang Lab is interested in the integrative analysis of large-scale datasets to understand the initiation and progression of diseases. The research projects involve in the development of highly accurate and sensitive computational methods for analyzing multidimensional omics data, especially in the area of detecting and analyzing genetic and transcriptomic alterations using second and third generation sequencing data. The long-term goal is to elucidate the genetic mechanisms of human diseases, such as cancer. Example projects span from technique-driven research that aims to develop algorithms for a wide range of applications to hypothesis-driven investigation of specific biological problems to fill the knowledge gap for a deeper understanding of biological systems.

There are four main areas of research:

  1. Genomic alterations detection: Genomic analysis of DNA using high-throughput sequencing to identify genetic alterations associated with human disorders
  2. Transcriptomic mis-splicing events discovery: Using short and long RNA sequencing to identify non-canonical splicing events that contribute to cancers
  3. Understanding lncRNA biology: Long noncoding RNAs (lncRNAs) are poorly annotated compared to coding genes; we aim to identify the disease-causing lncRNAs and their underlying mechanisms
  4. Tumor neoantigens and immunotherapy: Leveraging multi-omics data to identify neoantigens that are potential predictive biomarkers for a response to cancer immunotherapy

Technologies and methods

The Yang Lab is primarily a bioinformatic group that uses a wide range of genomic, bioinformatic, and statistical methods including: whole-exome sequencing, whole-genome sequencing, RNA-Seq, ChIP-Seq, and third-generation sequencing (PacBio and ONT).

Detailed technoical guide and lab documents can be found at the Lab Guide page.

Joining Yang Lab

If you are interested in joining please go to the recruitment page.

Funding

We are grateful for funding from the NIH/NCI, NIH/NIGMS, the US Department of Defense, the Prostate Cancer Foundation, the PhRMA Foundation, and the Chrodoma Foundation.

News

Nov 12th 2022

Dr. Yang give a talk of Multi-dimensional Data Integration for Prostate Cancer Research at the 30th annual meeting of Society of Basic Urologic Research

Sep 13th 2022

New tool detecting exitron splicing in long-read sequencing is published in Bioinformatics. Congrats to Josh and Yangyang!

Sep 1st 2022

Dr. Qingxiang Guo from Huangzhong Agricultural University joins us as a postdoctoral fellow. Welcome!

Jul 1st 2022

We have been awarded a research grant from the Polsky Urologic Cancer Institute!

Jun 26th 2022

A book chapter on medium and large indel detection is publised in Methods in Molecular Biology

May 31st 2022

New Grant! The lab received an R01 from NCI to support our exitron splicing study. Cheers!

Mar 29th 2022

Our lab will move to Northwestern Feinberg School of Medicine in July. Cheers!

Nov 4th 2021

Collaborative paper with Dehm lab is published in Nature Communications.

Oct 1st 2021

We received a Windfeldt Cancer Research Award.

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